Jing Yu（余靓）, Fan Zhao, Weiliang Gao, Xue Yang, Yanmin Ju, Lingyun Zhao, Weisheng Guo, Jun Xie, Xing-jie Liang, Xinyong Tao, Juan Li, Yao Ying, Wangchang Li, Jingwu Zheng, Liang Qiao, Subin Xiong, Xiaozhou Mou, Shenglei Che, and Yanglong Hou

Zhejiang University of Technology, Zhejiang Provincial People’s Hospital, Peking University, Tsinghua University, National Center for Nanoscience and Technology, Jiangsu Normal University

By taking advantage of the intrinsic acidity and overproduction of H₂O₂ in the tumor environment, an ROS nanoreactor based on core-shell-structured iron carbide (Fe₅C₂@Fe₃O₄) nanoparticles (NPs) was developed through the catalysis of the Fenton reaction. These NPs are able to release ferrous ions in acidic environments to disproportionate H₂O₂ into •OH radicals, which effectively inhibits the proliferation of tumor cells both in vitro and in vivo. The high magnetization of Fe₅C₂@Fe₃O₄ NPs is favorable for both magnetic targeting and T₂-weighted magnetic resonance imaging (MRI). Ionization of these NPs simultaneously decreases the T₂ signal and enhances the T₁ signal in MRI, and this T₂/T₁ switching process provides the visualization of ferrous ions release and ROS generation for the supervision of tumor curing. These Fe₅C₂@Fe₃O₄ NPs show great potential in endogenous environment-excited cancer therapy with high efficiency and tumor specificity and can be guided further by MRI.

（2）基于SERS效应对水中肼类物质的痕量检测研究

谢拯

中国人民解放军火箭军工程大学

采用电子束蒸发的倾斜生长技术，在PS微球阵列上实现了具有高SERS活性、树枝状Ag纳米结构周期阵列的制备。建立了肼的快速、痕量的检测方法，揭示了Ag纳米结构、局域电磁场和SERS活性之间的关系。研究成果可指导高性能SERS基底的设计与构筑，实现对局域电磁场强度和分布的调控，对局域表面等离子激元和SERS检测领域的研究具有指导意义。

（3）高端芯片的Co基接触孔材料的可靠性分析

都安彦

中国科学院微电子研究所

随着特征尺寸不断缩小，由于晶粒边界散射和表面散射，导致互连线电阻快速上升。为了缓解这一问题，Co在金属化方案中作为Cu或W的替代材料具有很高的潜力。本研究采用Co作为局部接触孔互连材料，采用Co-Ti作为单层阻挡层/衬垫层来代替传统的厚TiN/Ti双层结构，为互联线保留更多有效体积，从而降低总的互联电阻。制备了含Co-Ti和不含Co-Ti的样品，研究了Co-Ti的阻挡特性。同时，在接触孔中对Co/Co-Ti与Si的反应机理进行了较全面的研究。为了进一步评价Co-Ti作为阻挡层的本征可靠性，在500 ℃下对样品进行了1分钟、30分钟和60分钟的退火处理，使用透射电镜（TEM）结合相应的电子能量损失谱（EELS），分析了不同温度时间退火后样品的界面形貌以及元素分布。

（4）奥氏体结构材料在高辐照剂量下的位错环缺陷演化

陈东钺

东京大学

在350⁰C时，Unfaulting现象几乎没有出现；而在400⁰C和450⁰C，Unfaulting现象都十分明显。在450⁰C有大量直径为12-20nm的Perfect loop生成，但也有不少更大尺寸的Frank loop没有发生Unfaulting演化。这说明Unfaulting过程中所谓的临界演变尺寸并不存在，也说明Frank loop的堆垛层错能不是Unfaulting的决定性因素。

（5）Anomalous lattice reconstruction during fracture of 2D ReS

赵炯

香港理工大学 应用物理学系

The monolayer 2D ReS₂ membrane experienced anomalous phase transition and lattice reconstruction (scheme shown in left panel) under the strain concentrated zone in the crack tips, as observed by high resolution atomic scale scanning transition electron microscopy imaging (right panel). The tetragonal phases in 2D materials such as transition metal dichalcogenides (TMD) can have different fracture mechanisms from the bulk counterparts.

（6）兼具成骨和成血管活性的仿生骨修复材料研究

李林昊

北京航空航天大学生物与医学工程学院

所制备的不同功能化多壁碳纳米管能够和多种成骨活性多肽共价结合，并能保持成骨多肽的活性，从而促进成骨关联细胞粘附、增殖以及向成骨质方向分化。

（7）无铅卤化物双钙钛矿材料缺陷物理及合金化方法调控

尹放，徐健，周宇倩，刘剑波

先进材料教育部重点实验室，清华大学材料学院

图(a)：在富Ag（贫Br）的生长条件下，Cs₂AgInBr₆具有良好n型导电性质。图(b)：通过Bi元素和In元素的合金化形成有序基态结构，可以将带隙降低至1.81eV，而且带隙特征成功调整为直接带隙，这有利于应用于光伏领域。

（8）Physical metallurgy-guided machine learning and artificial intelligent design of ultrahigh-strength steel

Chi Zhang, Chenchong Wang, Chunguang Shen, Wei Xu

1. Key Laboratory of Advanced Materials of Ministry of Education, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China

2.State Key Laboratory of Rolling and Automation, Northeastern University, Shenyang, Liaoning, 110819, China

In order to make reasonable design for the improvement of comprehensive mechanical properties of ultrahigh-strength steels, the design system with both machine learning and high-throughput optimization algorithm was established. As the basis of the design system, a dataset of ultrahigh-strength steels was compiled from previous literatures. Then, feature engineering guided machine learning model were trained by the dataset and NSGA II algorithm were used for the selection of the optimal solutions from the large-scale solution set with composition features and treatment processing features. The selected optimal solutions by this design system showed prospective mechanical properties, which was also consistent with the physical metallurgy theory. This efficiency design mode could give the enlightenment for the design of other metal structural materials with the requirement of multi-properties

（9）Hardening through an Ultrafine Carbide Precipitation in Austenite of a Low-Carbon Steel Containing Titanium and Tungsten

Zhenqiang Wang

Harbin Engineering University

A significant hardening effect was obtained in a low carbon steel containing Ti and W by performing a 20% hot compressive deformation and 60s stress-relaxation at 1148-1198K (875-925oC) in the austenite region. TEM observation indicated that the hardening effect in martensite and bainite was closely associated with a fine dispersion of ultrafine precipitates with particle size of 1-10 nm at peak hardness. These ultrafine precipitates were identified as W, Fe-rich (WFeTi)C carbides with MC-type B1 structure, the crystal parameter of which is quite similar to austenite matrix. Excluding other strengthening factors, the yield strength increment from precipitation hardening of carbides was estimated to be about 33-179MPa at the studied temperature of 1198K (925oC).